You took the medication. You gave it time. When it did not help enough, you tried another.
Maybe you experienced side effects without meaningful relief. Maybe your symptoms improved for a while and then returned. Or maybe you are still going to work, taking care of your family, and holding everything together while privately wondering how long you can keep doing this.
When depression continues despite more than one appropriate treatment attempt, it may be considered treatment-resistant depression.
That does not mean you are beyond help. It means the treatments you have tried have not been enough—and it may be time to consider a different approach.
At Claritiv Health, IV ketamine infusion therapy may be one option for eligible adults with treatment-resistant depression. We do not recommend it automatically, and we do not treat it as a quick fix. We begin with a psychiatric evaluation, look closely at your treatment history, and determine whether IV ketamine makes sense as part of your broader care plan.
What Is Treatment-Resistant Depression?
Treatment-resistant depression generally describes depression that has not improved enough after at least two adequate antidepressant trials.
An adequate trial usually involves taking the medication consistently, at an appropriate dose, for enough time to evaluate its effect. But counting medications does not tell the whole story.
We also need to understand:
- Whether you experienced any partial improvement
- How long the improvement lasted
- Which symptoms remained
- Whether side effects limited treatment
- Why each medication was changed or stopped
- Whether the original diagnosis still fits
- Whether another condition or medical concern may be affecting your response
Some people with treatment-resistant depression remain deeply impaired. Others keep functioning outwardly but feel numb, exhausted, disconnected, or unable to experience the parts of life that once mattered.
Both deserve to be taken seriously.
Why Might IV Ketamine Be Considered?
Most conventional antidepressants affect chemical messenger systems involving serotonin, norepinephrine, or dopamine. These medications help many people, but they do not bring sufficient relief for everyone.
Ketamine works differently.
Its effects involve the brain’s glutamate system, including receptors associated with communication and adaptability between brain cells. Researchers continue to study the full process, but this different pathway is one reason IV ketamine has received attention as a potential option for adults whose depression has not responded adequately to conventional treatment.
A different mechanism does not guarantee a different result. It does give us another approach to consider when repeating the same treatment strategy is no longer enough.
How Quickly Can IV Ketamine Affect Depression Symptoms?
One reason ketamine has changed the conversation around difficult-to-treat depression is the speed of response observed in some clinical studies.
Conventional antidepressants often take several weeks to produce noticeable improvement. Some adults who respond to IV ketamine may notice changes within a day or over the following days.
But faster is not the same as guaranteed.
Some patients respond early. Others notice more gradual changes across a series of treatments. Some experience partial improvement, and some do not experience meaningful relief.
We will never promise that you will feel different after one infusion. We track your response over time and make decisions based on what is actually happening—not what happened for someone else.
Why Do We Begin With a Psychiatric Evaluation?
IV ketamine is not the right next step for every person with depression.
Before recommending treatment, we need to understand your full story. At Claritiv Health, comprehensive care begins with a psychiatric evaluation that may include your:
- Current symptoms
- Psychiatric and medical history
- Previous diagnoses
- Medication history
- Prior treatment responses
- Current medications
- Substance-use history
- Treatment goals
We also look for factors that could affect your diagnosis, safety, or treatment plan.
For example, depressive symptoms can occur in both major depressive disorder and bipolar disorder, but those conditions require different clinical considerations. Anxiety, trauma, sleep problems, medical conditions, medication effects, and substance use may also influence how depression appears and responds to care.
The evaluation helps us determine whether IV ketamine may be appropriate, whether another part of your care should be addressed first, or whether a different treatment direction makes more sense.
We are not here to guide every patient toward an infusion. We are here to recommend care that fits the person in front of us.
What Does IV Ketamine Treatment Involve?
When we recommend IV ketamine for treatment-resistant depression, the medication is administered directly into a vein in a controlled clinical setting.
Our standard induction course consists of six infusions over approximately two to three weeks. Each infusion generally lasts 40 to 60 minutes.
During treatment, you remain conscious and able to communicate with us. We continuously monitor your blood pressure, heart rate, and oxygen level, with vital signs checked at regular intervals.
Your infusion takes place in a private suite designed around comfort and discretion. Depending on your preferences, the setting may include:
- Soft or dimmed lighting
- Calming ambient music
- A weighted blanket
- An eye mask
- Noise-canceling headphones
When the infusion ends, you remain with us for approximately 20 to 30 minutes while the immediate effects wear off. Your first treatment visit may take approximately 90 minutes to two hours from arrival through recovery.
You will need a responsible adult to drive you home. You should not drive, operate machinery, or make major decisions for 24 hours after treatment.
Why Is IV Administration Used?
IV administration allows us to deliver ketamine in a controlled, medically supervised setting while monitoring how you respond throughout the session.
That matters because ketamine can temporarily affect perception, blood pressure, heart rate, balance, and alertness. The treatment process includes screening, preparation, monitoring, recovery, and follow-up—not simply receiving the medication and going home.
What Might You Feel During an Infusion?
Every person experiences IV ketamine differently.
You may feel relaxed or notice changes in your awareness of time, your body, or the room around you. Some people describe feeling light, dreamlike, distant, or detached.
Temporary effects may also include:
- Dizziness
- Nausea
- Blurred vision
- Changes in perception
- A sense of disconnection from your surroundings
- Temporary increases in blood pressure or heart rate
You remain conscious and able to communicate with us. We stay nearby throughout the infusion so you can tell us if you feel anxious, uncomfortable, or need reassurance.
The immediate effects generally begin to ease after the infusion ends.
Why Is Treatment Usually Given as a Series?
A single infusion may provide useful information, but it does not always show us the full picture.
Research has examined both single and repeated IV ketamine infusions for treatment-resistant depression. Repeated treatment may help us evaluate whether improvement builds or becomes more consistent across a series.
That is why our standard induction course includes six infusions rather than treating one appointment as the final answer.
Across the series, we look at more than a single good or bad day. We track patterns such as:
- Changes in mood
- Interest or enjoyment
- Energy and motivation
- Sleep
- Concentration
- Daily functioning
- Side effects
- How long any improvement lasts
Your progress should be measured against your own starting point—not against someone else’s experience.
What Happens After the Initial Series?
After the induction series, we review how you responded and what the next phase of care should involve.
Some patients who benefit from treatment may be considered for maintenance infusions. These are personalized according to response and ongoing need and may occur every two to eight weeks. Some people may eventually extend the time between appointments.
Maintenance is not automatic. We do not continue treatment simply because a standard schedule says we should.
We look at whether the benefits remain meaningful, whether side effects are manageable, how long improvement lasts, and how IV ketamine fits into the rest of your care.
IV Ketamine Is Not a Standalone Cure
Depression affects more than brain chemistry. It can shape your sleep, relationships, routines, confidence, physical health, and ability to engage with daily life.
IV ketamine may help some eligible adults experience meaningful improvement, but it does not erase every stressor or rebuild every part of life on its own.
Depending on your needs, your broader plan may also include:
- Medication management
- Talk Therapy
- Ongoing psychiatric follow-up
- Changes that support sleep, structure, and daily functioning
We see IV ketamine as one potential part of comprehensive care—not a replacement for it.
Our role is to help you understand how the pieces fit together and adjust the plan as your needs change.
Is IV Ketamine FDA-Approved for Depression?
Ketamine is FDA-approved as an anesthetic. Its use for depression is off-label.
Off-label use means an approved medication is being used for a purpose that is not included in its FDA-approved labeling. Clinicians may use medications off-label when they determine that doing so is medically appropriate, but the distinction should be explained clearly.
IV ketamine is not FDA-approved for treatment-resistant depression. That is why honest informed consent, individualized evaluation, medical monitoring, and a clear discussion of potential benefits, limitations, and risks are essential.
Is IV Ketamine Right for You?
Reading about IV ketamine cannot tell you whether you are a candidate.
That decision depends on your diagnosis, medical history, medications, previous treatments, current symptoms, and the risks and potential benefits in your specific situation.
You may be a strong candidate. You may need another part of your treatment plan addressed first. Or we may determine that IV ketamine is not the right direction for you.
We will tell you honestly.
The purpose of an evaluation is not to sell you an infusion. It is to understand why you are still struggling and identify the most appropriate next step.
IV Ketamine for Treatment-Resistant Depression in Jackson, Tennessee
You may have spent years moving through the same cycle: start a medication, wait, adjust it, and start again.
At some point, asking about a different approach is not giving up on treatment.
It is asking treatment to do more.
At Claritiv Health, we provide private, comprehensive mental health care for adults in Jackson and across West Tennessee. We bring psychiatric evaluation, medication management, Talk Therapy, and IV ketamine infusion therapy together under one roof so your care can reflect the full picture.
You do not need to decide whether IV ketamine is right for you before reaching out.
That is what the evaluation is for.
Book a private consultation with Claritiv Health to begin the conversation.
This article is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Ketamine is FDA-approved as an anesthetic. Its use for depression is off-label. Eligibility and treatment recommendations depend on an individualized clinical evaluation.
Works Cited
Fava, M., Freeman, M. P., Flynn, M., Judge, H., Hoeppner, B. B., Cusin, C., Ionescu, D. F., Mathew, S. J., Chang, L. C., Iosifescu, D. V., Murrough, J., Debattista, C., Schatzberg, A. F., Trivedi, M. H., Jha, M. K., Sanacora, G., Wilkinson, S. T., Papakostas, G. I., & Mischoulon, D. (2020). Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression. Molecular Psychiatry, 25(7), 1592–1603.
Marcantoni, W. S., Akoumba, B. S., Wassef, M., Mayrand, J., Lai, H., Richard-Devantoy, S., & Beauchamp, S. (2020). A systematic review and meta-analysis of the efficacy of intravenous ketamine infusion for treatment-resistant depression: January 2009–January 2019. Journal of Affective Disorders, 277, 831–841.
National Institute of Mental Health. (2024). New hope for rapid-acting depression treatment. National Institutes of Health.
Phillips, J. L., Norris, S., Talbot, J., Birmingham, M., Hatchard, T., Ortiz, A., Owoeye, O., Batten, L. A., & Blier, P. (2019). Single, repeated, and maintenance ketamine infusions for treatment-resistant depression: A randomized controlled trial. American Journal of Psychiatry, 176(5), 401–409.
U.S. Food and Drug Administration. (2024). Understanding current use of ketamine for emerging areas of therapeutic interest.